Signal Transduction

Signal Transduction PDF
Author: Ijsbrand M. Kramer
Publisher: Academic Press
ISBN: 0123948193
Size: 15.57 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 1104
View: 6530

Get Book



Book Description:

Signal Transduction

by Ijsbrand M. Kramer, Signal Transduction Book available in PDF, EPUB, Mobi Format. Download Signal Transduction books, A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and adhesion molecules. In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor – ligand interactions to post-translational modifications operational in the process of bringing about cellular changes. The phosphorylation process, from bacteria to men, is discussed in detail. Signal transduction third edition further elaborates on diverse signaling cascades within particular contexts such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite, oncogenic transformation and cell fate decision during development or in stem cell niches. The subjects have been enriched with descriptions of the relevant anatomical, histological, physiological or pathological condition. In-depth insight into a subject central to cell biology and fundamental to biomedicine, including the search for novel therapeutic interventions Essential signaling events embedded in rich physiological and pathological contexts Extensive conceptual colour artwork to assist with comprehension of key topics Special emphasis on how molecular structure determines protein function and subcellular localization Employment of unambiguous protein names (symbols) in agreement with leading protein- and gene databases, allowing the learner to extend his/her exploration on the web







Role Of Signal Transduction Cascade In Activation Of Mitogen Activated Protein Kinase And Cytosolic Phospholipase A 1tn2 In Human Polymorphonuclear Neutrophils

Role of Signal Transduction Cascade in Activation of Mitogen Activated Protein Kinase and Cytosolic Phospholipase A 1tn2 in Human Polymorphonuclear Neutrophils PDF
Author: Hong Zhang
Publisher:
ISBN:
Size: 20.35 MB
Format: PDF, ePub
Category :
Languages : en
Pages : 172
View: 4212

Get Book



Book Description:

Role Of Signal Transduction Cascade In Activation Of Mitogen Activated Protein Kinase And Cytosolic Phospholipase A 1tn2 In Human Polymorphonuclear Neutrophils

by Hong Zhang, Role Of Signal Transduction Cascade In Activation Of Mitogen Activated Protein Kinase And Cytosolic Phospholipase A 1tn2 In Human Polymorphonuclear Neutrophils Book available in PDF, EPUB, Mobi Format. Download Role Of Signal Transduction Cascade In Activation Of Mitogen Activated Protein Kinase And Cytosolic Phospholipase A 1tn2 In Human Polymorphonuclear Neutrophils books,







Hormone Perception And Signal Transduction In Animals And Plants

Hormone Perception and Signal Transduction in Animals and Plants PDF
Author: Jerry Roberts
Publisher:
ISBN:
Size: 54.95 MB
Format: PDF, Docs
Category : Cellular signal transduction
Languages : en
Pages : 323
View: 3934

Get Book



Book Description:

Hormone Perception And Signal Transduction In Animals And Plants

by Jerry Roberts, Hormone Perception And Signal Transduction In Animals And Plants Book available in PDF, EPUB, Mobi Format. Download Hormone Perception And Signal Transduction In Animals And Plants books,







Characterizing Signal Transduction Networks And Biological Responses Using Computer Simulations And Machine Learning

Characterizing Signal Transduction Networks and Biological Responses Using Computer Simulations and Machine Learning PDF
Author: Aaron Matthew Prescott
Publisher:
ISBN:
Size: 79.74 MB
Format: PDF, ePub, Mobi
Category : Biological response modifiers
Languages : en
Pages : 151
View: 2713

Get Book



Book Description:

Characterizing Signal Transduction Networks And Biological Responses Using Computer Simulations And Machine Learning

by Aaron Matthew Prescott, Characterizing Signal Transduction Networks And Biological Responses Using Computer Simulations And Machine Learning Book available in PDF, EPUB, Mobi Format. Download Characterizing Signal Transduction Networks And Biological Responses Using Computer Simulations And Machine Learning books, The use of computer simulations in biology is often limited due to the lack of experimentally measured parameters. In these scenarios, parameter exploration can be used to probe biological systems and refine understanding of biological mechanisms. For systems with few unknown parameters, parameter sweeps that concurrently vary all unknown parameters are tractable. In complex systems with many unknown parameters, supervised machine learning algorithms can be used to discover parameters leading to targeted system responses. In this thesis, we study three biological problems in which we use parameter exploration methods to gain mechanistic insights. We first explore the role of altered metabolism in cancer cells that reside in heterogeneous tumor microenvironments. We use a multiscale, hybrid cellular automaton model to evaluate tumor progression while varying malignant cell traits using a systematic parameter sweep. The results reveal distinct growth regimes associated with varied malignant cell traits. We then study kinetic mechanisms governing fixed-topology signal transduction networks and use evolutionary algorithms to discover kinetic parameters that produce specified network responses. We analyze the growth-response network in Arabidopsis with this supervised machine learning approach. This allows us to identify constraints on kinetic parameters that govern the observed responses. The evolved parameters are used to calculate the responses of individual network components, which are used to generate hypotheses that can be tested in vivo to help determine the network topology. We finally apply a similar approach to redesign signal transduction networks. We demonstrate that the T cell receptor network and an oscillator network show remarkable flexibility in generating altered responses to input, and we further use a nonlinear clustering method to identify design criteria for the underlying kinetic parameters. For each project, observations produced from in silico simulations lead to the formation of hypotheses that are experimentally testable.







Signal Transduction Pathways Mechanisms And Diseases

Signal Transduction  Pathways  Mechanisms and Diseases PDF
Author: Ari Sitaramayya
Publisher: Springer Science & Business Media
ISBN: 9783642021121
Size: 67.37 MB
Format: PDF
Category : Science
Languages : en
Pages : 437
View: 544

Get Book



Book Description:

Signal Transduction Pathways Mechanisms And Diseases

by Ari Sitaramayya, Signal Transduction Pathways Mechanisms And Diseases Book available in PDF, EPUB, Mobi Format. Download Signal Transduction Pathways Mechanisms And Diseases books, Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.







Signal Transduction

Signal Transduction PDF
Author: Gerard Meurant
Publisher: Academic Press
ISBN: 0323139124
Size: 47.30 MB
Format: PDF
Category : Science
Languages : en
Pages : 463
View: 5087

Get Book



Book Description:

Signal Transduction

by Gerard Meurant, Signal Transduction Book available in PDF, EPUB, Mobi Format. Download Signal Transduction books, An explosion of information has occurred over the past few years in the field of signal transduction. As information form prokaryotes and eukaryotes has accumulated, it has become evident that diverse sensory systems share common mechanistic themes. This volume reviews our the current knowledge of molecular mechanisms for sensory transduction in a variety of microbial systems, as well as elegant work done in nematodes and Drosophila. Signal Transduction is intended for both researchers studying microbial systems and investigators and students of signal transduction in more complex organisms, who can learn from the paradigms and mechanisms conserved between prokaryotes and eukaryotes.







Signal Transduction

Signal Transduction PDF
Author: Bastien D. Gomperts
Publisher: Gulf Professional Publishing
ISBN: 9780122896323
Size: 76.11 MB
Format: PDF
Category : Medical
Languages : en
Pages : 424
View: 1547

Get Book



Book Description:

Signal Transduction

by Bastien D. Gomperts, Signal Transduction Book available in PDF, EPUB, Mobi Format. Download Signal Transduction books, Signal Transduction now in paperback, is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix, etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particulary cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources key observations and experiments that set the scence for recent and current work. * Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine * Conceptual colour artwork assists with the comprehension of key topics * Extensive referencing provides an invaluable link to the core and historical literature * Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms







Signal Transduction In Plants

Signal Transduction in Plants PDF
Author: S.K. Sopory
Publisher: Springer Science & Business Media
ISBN: 1461513650
Size: 63.21 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 337
View: 1281

Get Book



Book Description:

Signal Transduction In Plants

by S.K. Sopory, Signal Transduction In Plants Book available in PDF, EPUB, Mobi Format. Download Signal Transduction In Plants books, An understanding of the mechanisms by which plants perceive environmental cues, both physical and chemical, and transduce the signals that influence specific expression of genes, is an area of intensive scientific research. With the completion of the genome sequence of Arabidopsis it is understood now that a larger number of genes encode for proteins involved in signalling cascades and transcription factors. In this volume, different chapters deal with plant receptors, second messengers like calcium ions, phosphoinositides, salicylic acid and nitrous oxide, calcium binding proteins and kinases. In addition to dealing with the response of plants to light, hormones, pathogens, heat, etc. on cellular activity, work currently going on in apoptosis, cell division, and plastid gene expression is also covered in this book.







Biochemistry Of Signal Transduction And Regulation

Biochemistry of Signal Transduction and Regulation PDF
Author: Gerhard Krauss
Publisher: John Wiley & Sons
ISBN: 3527667490
Size: 12.72 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 844
View: 4204

Get Book



Book Description:

Biochemistry Of Signal Transduction And Regulation

by Gerhard Krauss, Biochemistry Of Signal Transduction And Regulation Book available in PDF, EPUB, Mobi Format. Download Biochemistry Of Signal Transduction And Regulation books, Originally based on a graduate course taught by the author, this true classic has once again been extensively updated to incorporate key new findings in biological signaling. With over half of the content re-written, plus 70 brand new and 50 revised figures, this is the most up-to-date textbook on signaling available anywhere. Thanks to its clear structure, hundreds of illustrative drawings, as well as chapter introductions and newly added study questions, this text excels as a companion for a course on biological signaling, and equally as an introductory reference to the field for students and researchers. Generations of students and junior researchers have relied on "the Krauss" to find their way through the bewildering complexity of biological signaling pathways.







Signal Transduction

Signal Transduction PDF
Author: Carl-Henrik Heldin
Publisher: Garland Science
ISBN: 9780748740741
Size: 43.83 MB
Format: PDF
Category : Science
Languages : en
Pages : 365
View: 2053

Get Book



Book Description:

Signal Transduction

by Carl-Henrik Heldin, Signal Transduction Book available in PDF, EPUB, Mobi Format. Download Signal Transduction books, Signal Transduction was published in association with The International Union of Biochemistry and Molecular Biology. In a series of twenty-three short chapters, leading researchers provide cutting-edge reviews of signal transduction, and form cell membrane receptors through to gene regulation. Written for those with a basic understanding of molecular and cell biology, the book will be of particular interest to graduate students and researchers who need to grasp the principles of signal transduction.